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Primary lung angiosarcoma is extremely rare. It is often associated with pulmonary tuberculosis or histiocytosis X. The prognosis is poor. We report a case of primary pulmonary angiosarcoma in a 49-year-old woman, who had been treated with antituberculous drugs for pulmonary tuberculosis. The radiologic and histologic findings were suggestive of atypical carcinoid with sarcomatous differentiation. She died of lung cancer and metastasis to brain, liver and kidney 3 months later. Autopsy revealed a tumor in the upper lobe of the right lung measuring 3.5 x 2.5 x 1.5 cm. It consisted of a mixture of spindle-shaped cells arranged in interlacing fascicles with abundant cytoplasm. Histologic examination revealed solid sheets of tumor cells with dense eosinophilic cytoplasm and occasional cytoplasmic vacuoles. Tumor cells displayed interlacing fascicles and were focally separated by thin fibrovascular septa. Tumor cells were immunohistochemically positive for vimentin, CD34, and Factor VIII-related antigen, and negative for cytokeratin, desmin, S-100 protein, cytokeratin (AE1/AE3) and EMA. We thought this was a primary angiosarcoma of the lung.National Alliance of

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